ncRNA name | hsa-miR-141 |
ncRNA Category | miRNA |
Disease name | pterygium |
Species | Homo sapiens |
Tissues/Cell_line | pterygium and normal conjunctiva tissues |
Methods | microarray, qRT-PCR |
Expression pattern | down-regulated |
Functional description | The concerted down-regulation of four members from both clusters of the miR-200 family (miR-200a/-200b/-429 and miR-200c/-141), which are known to regulate EMT, and up-regulation of the predicted target and mesenchymal marker fibronectin (FN1), suggest that EMT could potentially play a role in the pathogenesis of pterygium and might constitute promising new targets for therapeutic intervention in pterygium. |
PubMed ID | 23872359 |
Year | 2013 |
Title | miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. |
Drug-related ncRNA | NO |
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